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KMID : 0614020090240010001
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Journal of Pharmaceutical Sciences (C.N.U.)
2009 Volume.24 No. 1 p.1 ~ p.10
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Chiral Analysis of Drugs in Clinical Applications
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Choi Hyun-Su
Chen Jianbo
Wu En-Qi
Lee Eun-Joo
Lee Eun-Sil
Park Kyung-Lae
Kang Jong-Seong
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Abstract
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Chirality plays an important role in biology, and many of the processes essential for life are stereospecific. Hence, the chiral chromatographic separation of drugs becomes more important for the pharmacologists and toxicologists to offer the appropriate tools to find the solution for many problems related with stereoisomers of drugs. This review discusses the clinical applications of chiral separation for meploquine salbutamol, omeprazole, ketamine and some fluorinated volatile inhalation anaesthetics. The chirality in clinical situations was illustrated by these drugs in the field of enantiospecific pharmacokinetics and therapeutic activities. The results indicated that the racemic switch to a single enantiomer for these drugs will promote the development of more effective and safe drugs.
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KEYWORD
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Chiral analysis, stereoisomer, clinicla application, pharmacokinetics, chiral drug
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